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Fentanyl Pills (also known as fentanil) is a potent, synthetic opioid pain medication with a rapid onset and short duration of action. It is a strong agonist at the μ-opioid receptors. Fentanyl is 50 and 100 times potent than morphine.
Paul Janssen made the pills in 1960,following the medical inception of pethidine several years earlier. Janssen developed fentanyl by assaying analogues of the structurally related drug pethidine for opioid activity. The widespread use of fentanyl triggered the production of fentanyl citrate (the salt formed by combining fentanyl and citric acid in a 1:1 stoichiometry), which entered medical use as a general anaesthetic under the trade name Sublimaze in the 1960s.
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Fentanyl Pills In the mid-1990s, fentanyl was introduced for palliative use with the fentanyl patch, followed in the next decade by the introduction of the fentanyl lollipop, dissolving tablets, and sublingual spray which are resorbed through the skin inside the mouth. As of 2012 fentanyl was the most widely used synthetic opioid in medicine. In 2013, 1700 kilograms were used globally.
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Also, the use of fentanyl has led to thousands of overdose deaths. Deaths have also resulted from improper medical use. Fentanyl has a relatively wide therapeutic index (270) which makes it a very safe surgical anesthetic when monitored carefully; however, its extreme potency requires careful measurements of highly diluted fentanyl in solution; attempting to accurately measure a dose of pure fentanyl powder is impractical.
Facts About Fentanyl
- Fentanyl can lead to addiction.
- Fentanyl and other synthetic opioids are the most common drugs involved in overdose deaths.
- Illegal fentanyl is being mixed with other drugs, such as cocaine, heroin, methamphetamine, and MDMA. This is especially dangerous because people are often unaware that fentanyl has been added.
- Fentanyl works by binding to the body’s opioid receptors, which are found in areas of the brain that control pain and emotions.
- Its effects include extreme happiness, drowsiness, nausea, confusion, constipation, sedation, tolerance, addiction, respiratory depression and arrest, unconsciousness, coma, and death.
- The high potency of fentanyl greatly increases risk of overdose, especially if a person who uses drugs is unaware that a powder or pill contains it. They can underestimate the dose of opioids they are taking, resulting in overdose.
- Naloxone is a medicine that can be given to a person to reverse a fentanyl overdose. Multiple naloxone doses might be necessary because of fentanyl’s potency.Buy fentanyl pills online without prescription
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